ANTIADRENERGIC DRUGS
ALPHA ADRENERGIC BLOCKING
DRUGS
(1)
PHENOXYBENZEMINE:-It
cycylizes spontaneously in the body giving rise to a highly reactive
ethyleniminium intermediate which reacts with alpha adrenoceptors and other
biomolecules by forming strong covalent bonds. It is lipid soluble penetrates
brain and can produce cns stimulation nausea and vomiting on rapid I.V.
injection.
(2)
TOLAZOLINE:-
It is an imidazole compound with complex pharmacological properties. Tolazoline
also bloks 5-HT recepters has a histamine like gastric secretagogue . it is
used in pheripheral vascular diseases and pulmonary hypertension of the
newborn.
(3)
DOXAZOSIN:-Used
in hypertension and benig hypertrophy of prostate(BPH).
(4)
TAMSULOSIN:-Used
in BPH patients
BETA
ADRENERGIC BLOCKING
DRUGS
CLSSIFICATION:-
(1)
Nonselective
Propranolol
Sotalol
Timolol
Pindolol
Labetalol
Carvedilol
(2)
CARDIOSELECTIVE
Metoprolol
Atenolol
Acebutolol
Bisoprolol
Esmolol
Betaxolol
Celiprolol
Nebivolol
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