ANTI
HISTAMIN DRUG
HISTAMINE
Histamine meaning tissue – Amine
Is almost ubiquitously present in animal tissues and in
certain plants e.g. stinging nettle.
Histamine is present mostly within storage granules of mast
cells. Tissues rich in histamine are skin gastric and intestinal mucosa, lungs,
liver and placenta. Nonmast cell histamine occurs in brain, epidermis,gastric
mucosa and growing regions.
CLINICAL CLASSIFICATION ANTI HISTAMINE DRUGS
(1)
HIGHLY SEDATIVE
DIPHENHYDRAMINE
DIMENHYDRINATE
PROMETHAZINE
HYDROXYZIINE
(2)
MODERATELY SEDATIVE
PHENIRAMINE
CYPROHEPTADINE
MECLIZINE
BUCLIZINE
CINNARIZINE
(3)
MILD SEDATIVE
CHLORPHENIRAMINE
DEXCHLORPHENIRAMINE
DIMETHAINDENE
TRIPROLIDINE
MEBHYDROLINE
CYHLIZINE
CLMASTINE
(4)
SECOND GENERATION ANTI HISTAMINICS
FEXOFENADINE
LORATADINE
DESLORATADINE
CETRIZINE
LEVOCETRIZINE
AZELASTINE
MIZOLASTINE
EBASTINE
RUPATADINE
USES
(1)
ALLERGIC DISORDERS
(2)
POISONING
(3)
PRURITIDES
(4)
COMMON COLD
(5)
MOTION SICKNESS
(6)
VERTIGO
(7)
PREANAESTHETIC MEDICATION
(8)
COUGH
(9)
PARKINSONISM
(10) ACUTE MUSCLE DYSTONIA
(11) AS SEDATIVE
(12) HYPNOTIC
(13) ANXIOLYTIC
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